Symptoms
Rapise works slow, fails to connect to Firefox or Chrome.
Reason
The reason for this is Defender Run-time protection that checks JavaScript files of Rapise Engine.

Resolution
Add an Exclusion for Rapise installation folder: c:\Program Files (x86)\Inflectra\Rapise

If in the Task Manager you see that RapiseLauncher.exe is consuming a lot of memory while running tests, then add it to exclusions as well:
C:\Program Files (x86)\Inflectra\Rapise\Bin\RapiseLauncher.exe
Same rule applies to cscript.exe:
C:\Windows\SysWOW64\cscript.exe