The Solution
The solution is to disable the Protected View setting within Excel. To do this, please do the following:
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Open MS Excel
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Go to File > Options
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Click Trust Center (from the menu on the left)
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Click the 'Trust Center Settings' button
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Click Protected View (from the menu on the left)
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Remove the check mark next to "Enable Protected View for files originating from the internet"
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Click OK
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Click OK
Now you will be able to open Excel reports from Spira.